Ontology highlight
ABSTRACT:
SUBMITTER: Demeyer A
PROVIDER: S-EPMC7522757 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Demeyer Annelies A Driege Yasmine Y Skordos Ioannis I Coudenys Julie J Lemeire Kelly K Elewaut Dirk D Staal Jens J Beyaert Rudi R
iScience 20200912 10
The protease MALT1 is a key regulator of NF-κB signaling and a novel therapeutic target in autoimmunity and cancer. Initial enthusiasm supported by preclinical results with MALT1 inhibitors was tempered by studies showing that germline MALT1 protease inactivation in mice results in reduced regulatory T cells and lethal multi-organ inflammation due to expansion of IFN-γ-producing T cells. However, we show that long-term MALT1 inactivation, starting in adulthood, is not associated with severe syst ...[more]