SARS-CoV-2 antibody signatures robustly predict diverse antiviral functions relevant for convalescent plasma therapy.
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ABSTRACT:
SUBMITTER: Natarajan H
PROVIDER: S-EPMC7523138 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
SARS-CoV-2 antibody signatures robustly predict diverse antiviral functions relevant for convalescent plasma therapy.
Natarajan Harini H Crowley Andrew R AR Butler Savannah E SE Xu Shiwei S Weiner Joshua A JA Bloch Evan M EM Littlefield Kirsten K Wieland-Alter Wendy W Connor Ruth I RI Wright Peter F PF Benner Sarah E SE Bonny Tania S TS Laeyendecker Oliver O Sullivan David D Shoham Shmuel S Quinn Thomas C TC Larman H Benjamin HB Casadevall Arturo A Pekosz Andrew A Redd Andrew D AD Tobian Aaron A R AAR Ackerman Margaret E ME
medRxiv : the preprint server for health sciences 20200918
Convalescent plasma has emerged as a promising COVID-19 treatment. However, the humoral factors that contribute to efficacy are poorly understood. This study functionally and phenotypically profiled plasma from eligible convalescent donors. In addition to viral neutralization, convalescent plasma contained antibodies capable of mediating such Fc-dependent functions as complement activation, phagocytosis and antibody-dependent cellular cytotoxicity against SARS-CoV-2. These activities expand the ...[more]
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