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Significance of Lymphovascular Space Invasion by the Sarcomatous Component in Uterine Carcinosarcoma.


ABSTRACT: OBJECTIVE:The aim of this study was to examine the significance of lymphovascular space invasion (LVSI) with a sarcomatous component on the tumor characteristics and clinical outcomes of women with uterine carcinosarcoma (UCS). METHODS:This was a secondary analysis of a prior multicenter retrospective study that examined women with stage I-IV UCS who underwent primary hysterectomy. Archived histopathology slides were reviewed and LVSI was scored as follows: LVSI with a carcinomatous component alone (LVSI-carcinoma; n?=?375, 76.8%) or LVSI containing a sarcomatous component with or without a carcinomatous component (LVSI-sarcoma; n?=?113, 23.2%). Qualitative metrics of LVSI were correlated to clinicopathological factors and survival outcome. RESULTS:Tumors in the LVSI-sarcoma group were more likely to have sarcoma dominance (82.1 vs. 26.4%) heterologous sarcomatous component (51.3 vs. 37.9%), low-grade carcinoma (42.5 vs. 22.4%), and large tumor size (81.0 vs. 70.2%) in the primary tumor site compared with tumors in the LVSI-carcinoma group (all p?

SUBMITTER: Matsuo K 

PROVIDER: S-EPMC7523233 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Significance of Lymphovascular Space Invasion by the Sarcomatous Component in Uterine Carcinosarcoma.

Matsuo Koji K   Takazawa Yutaka Y   Ross Malcolm S MS   Elishaev Esther E   Yunokawa Mayu M   Sheridan Todd B TB   Bush Stephen H SH   Klobocista Merieme M MM   Blake Erin A EA   Takano Tadao T   Baba Tsukasa T   Satoh Shinya S   Shida Masako M   Ikeda Yuji Y   Adachi Sosuke S   Yokoyama Takuhei T   Takekuma Munetaka M   Yanai Shiori S   Takeuchi Satoshi S   Nishimura Masato M   Iwasaki Keita K   Johnson Marian S MS   Yoshida Masayuki M   Hakam Ardeshir A   Machida Hiroko H   Mhawech-Fauceglia Paulette P   Ueda Yutaka Y   Yoshino Kiyoshi K   Kajiwara Hiroshi H   Hasegawa Kosei K   Yasuda Masanori M   Miyake Takahito M TM   Moriya Takuya T   Yuba Yoshiaki Y   Morgan Terry T   Fukagawa Tomoyuki T   Pejovic Tanja T   Nagano Tadayoshi T   Sasaki Takeshi T   Richmond Abby M AM   Post Miriam D MD   Shahzad Mian M K MMK   Im Dwight D DD   Yoshida Hiroshi H   Enomoto Takayuki T   Omatsu Kohei K   Ueland Frederick R FR   Kelley Joseph L JL   Karabakhtsian Rouzan G RG   Roman Lynda D LD  

Annals of surgical oncology 20180703 9


<h4>Objective</h4>The aim of this study was to examine the significance of lymphovascular space invasion (LVSI) with a sarcomatous component on the tumor characteristics and clinical outcomes of women with uterine carcinosarcoma (UCS).<h4>Methods</h4>This was a secondary analysis of a prior multicenter retrospective study that examined women with stage I-IV UCS who underwent primary hysterectomy. Archived histopathology slides were reviewed and LVSI was scored as follows: LVSI with a carcinomato  ...[more]

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