Unknown

Dataset Information

0

Tumor Microenvironment Targeting Nano-Bio Emulsion for Synergistic Combinational X-Ray PDT with Oncolytic Bacteria Therapy.


ABSTRACT: Various cancer therapies have been developed, but tumor recurrence with incomplete tumor killing and remaining tumor cells/tissues is frequent in monotherapies. Herein, a nano-bio therapeutic emulsion formulated with multifunctional nanoscintillators and anaerobic Clostridium novyi-NT spores for synergistic image-guided combinational cancer therapy is reported. MRI visible nanoscintillators (NSs) are synthesized with a NaGdF4 :Tb,Ce@NaGdF4 core/shell structure for an image-guided X-ray photodynamic therapy (PDT) of the normoxic peripheral tumor. An anaerobic oncolytic bacterium (C. novyi-NT) therapy is combined to treat the hypoxic central tumor tissues. Photosensitizer-coated NSs (PS-NSs) and C. novyi-NT spores are emulsified with clinically available ethiodized oil (Lipiodol) to be the nano-bio therapeutic emulsion and injected into the tumor with computed tomography image guidance. The distribution of nano-bio therapeutic emulsion, including PS-NSs and anaerobic C. novyi-NT spores in the tumor site, is confirmed by both X-ray and T1 -weighted magnetic resonance imaging. Following the image-guided X-ray PDT and anaerobic C. novyi- NT combination treatment, apoptotic cell death in cancer tissues, including both peripheral and central tumor regions, is significantly higher than in the control groups. This combination therapy approach using a nano-bio therapeutic emulsion is expected to overcome the limitations of conventional cancer therapy, resulting in increased cancer-therapeutic efficacy.

SUBMITTER: Park W 

PROVIDER: S-EPMC7523430 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6096451 | biostudies-literature
| S-EPMC7820612 | biostudies-literature
| S-EPMC6680913 | biostudies-literature
| S-EPMC6386558 | biostudies-literature
2024-08-01 | GSE211069 | GEO
| S-EPMC8161808 | biostudies-literature
| S-EPMC2890112 | biostudies-other
| S-EPMC2881175 | biostudies-other
| S-EPMC11321614 | biostudies-literature
| S-EPMC7956262 | biostudies-literature