Dataset Information

Training and Validation of Deep Neural Networks for the Prediction of 90-Day Post-Liver Transplant Mortality Using UNOS Registry Data.

ABSTRACT: Prediction models of post-liver transplant mortality are crucial so that donor organs are not allocated to recipients with unreasonably high probabilities of mortality. Machine learning algorithms, particularly deep neural networks (DNNs), can often achieve higher predictive performance than conventional models. In this study, we trained a DNN to predict 90-day post-transplant mortality using preoperative variables and compared the performance to that of the Survival Outcomes Following Liver Transplantation (SOFT) and Balance of Risk (BAR) scores, using United Network of Organ Sharing data on adult patients who received a deceased donor liver transplant between 2005 and 2015 (n = 57,544). The DNN was trained using 202 features, and the best DNN's architecture consisted of 5 hidden layers with 110 neurons each. The area under the receiver operating characteristics curve (AUC) of the best DNN model was 0.703 (95% CI: 0.682-0.726) as compared to 0.655 (95% CI: 0.633-0.678) and 0.688 (95% CI: 0.667-0.711) for the BAR score and SOFT score, respectively. In conclusion, despite the complexity of DNN, it did not achieve a significantly higher discriminative performance than the SOFT score. Future risk models will likely benefit from the inclusion of other data sources, including high-resolution clinical features for which DNNs are particularly apt to outperform conventional statistical methods.

SUBMITTER: Ershoff BD

PROVIDER: S-EPMC7523496 | biostudies-literature | 2020 Jan - Feb

REPOSITORIES: biostudies-literature

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Training and Validation of Deep Neural Networks for the Prediction of 90-Day Post-Liver Transplant Mortality Using UNOS Registry Data.

Ershoff Brent D BD Lee Christine K CK Wray Christopher L CL Agopian Vatche G VG Urban Gregor G Baldi Pierre P Cannesson Maxime M

Transplantation proceedings 20200108 1

Prediction models of post-liver transplant mortality are crucial so that donor organs are not allocated to recipients with unreasonably high probabilities of mortality. Machine learning algorithms, particularly deep neural networks (DNNs), can often achieve higher predictive performance than conventional models. In this study, we trained a DNN to predict 90-day post-transplant mortality using preoperative variables and compared the performance to that of the Survival Outcomes Following Liver Tra ...[more]

PMID: 31926745

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Project description:The learning process and hyper-parameter optimization of artificial neural networks (ANNs) and deep learning (DL) architectures is considered one of the most challenging machine learning problems. Several past studies have used gradient-based back propagation methods to train DL architectures. However, gradient-based methods have major drawbacks such as stucking at local minimums in multi-objective cost functions, expensive execution time due to calculating gradient information with thousands of iterations and needing the cost functions to be continuous. Since training the ANNs and DLs is an NP-hard optimization problem, their structure and parameters optimization using the meta-heuristic (MH) algorithms has been considerably raised. MH algorithms can accurately formulate the optimal estimation of DL components (such as hyper-parameter, weights, number of layers, number of neurons, learning rate, etc.). This paper provides a comprehensive review of the optimization of ANNs and DLs using MH algorithms. In this paper, we have reviewed the latest developments in the use of MH algorithms in the DL and ANN methods, presented their disadvantages and advantages, and pointed out some research directions to fill the gaps between MHs and DL methods. Moreover, it has been explained that the evolutionary hybrid architecture still has limited applicability in the literature. Also, this paper classifies the latest MH algorithms in the literature to demonstrate their effectiveness in DL and ANN training for various applications. Most researchers tend to extend novel hybrid algorithms by combining MHs to optimize the hyper-parameters of DLs and ANNs. The development of hybrid MHs helps improving algorithms performance and capable of solving complex optimization problems. In general, the optimal performance of the MHs should be able to achieve a suitable trade-off between exploration and exploitation features. Hence, this paper tries to summarize various MH algorithms in terms of the convergence trend, exploration, exploitation, and the ability to avoid local minima. The integration of MH with DLs is expected to accelerate the training process in the coming few years. However, relevant publications in this way are still rare.

Dataset Information

Training and Validation of Deep Neural Networks for the Prediction of 90-Day Post-Liver Transplant Mortality Using UNOS Registry Data.

Publications

Training and Validation of Deep Neural Networks for the Prediction of 90-Day Post-Liver Transplant Mortality Using UNOS Registry Data.

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