Toward guiding principles for the design of biologically-integrated electrodes for the central nervous system.

ABSTRACT: Innovation in electrode design has produced a myriad of new and creative strategies for interfacing the nervous system with softer, less invasive, more broadly distributed sites with high spatial resolution. However, despite rapid growth in the use of implanted electrode arrays in research and clinical applications, there are no broadly accepted guiding principles for the design of biocompatible chronic recording interfaces in the central nervous system (CNS). Studies suggest that the architecture and flexibility of devices play important roles in determining effective tissue integration: device feature dimensions (varying from 'sub'- to 'supra'-cellular scales, <10 µm to  >100 µm), Young's modulus, and bending modulus have all been identified as key features of design. However, critical k

SUBMITTER: Thompson CH 

PROVIDER: S-EPMC7523527 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature