Ontology highlight
ABSTRACT:
SUBMITTER: Pfefferle M
PROVIDER: S-EPMC7524492 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Pfefferlé Marc M Ingoglia Giada G Schaer Christian A CA Yalamanoglu Ayla A Buzzi Raphael R Dubach Irina L IL Tan Ge G López-Cano Emilio Y EY Schulthess Nadja N Hansen Kerstin K Humar Rok R Schaer Dominik J DJ Vallelian Florence F
The Journal of clinical investigation 20201001 10
During hemolysis, macrophages in the liver phagocytose damaged erythrocytes to prevent the toxic effects of cell-free hemoglobin and heme. It remains unclear how this homeostatic process modulates phagocyte functions in inflammatory diseases. Using a genetic mouse model of spherocytosis and single-cell RNA sequencing, we found that erythrophagocytosis skewed liver macrophages into an antiinflammatory phenotype that we defined as MarcohiHmoxhiMHC class IIlo erythrophagocytes. This phenotype trans ...[more]