Ontology highlight
ABSTRACT:
SUBMITTER: Ganatra SR
PROVIDER: S-EPMC7524506 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Ganatra Shashank R SR Bucşan Allison N AN Alvarez Xavier X Kumar Shyamesh S Chatterjee Ayan A Quezada Melanie M Fish Abigail A Singh Dhiraj K DK Singh Bindu B Sharan Riti R Lee Tae-Hyung TH Shanmugasundaram Uma U Velu Vijayakumar V Khader Shabaana A SA Mehra Smriti S Rengarajan Jyothi J Kaushal Deepak D
The Journal of clinical investigation 20201001 10
While the advent of combination antiretroviral therapy (ART) has significantly improved survival, tuberculosis (TB) remains the leading cause of death in the HIV-infected population. We used Mycobacterium tuberculosis/simian immunodeficiency virus-coinfected (M. tuberculosis/SIV-coinfected) macaques to model M. tuberculosis/HIV coinfection and study the impact of ART on TB reactivation due to HIV infection. Although ART significantly reduced viral loads and increased CD4+ T cell counts in blood ...[more]