Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC7524507 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Yang Ying Y Neo Shi Yong SY Chen Ziqing Z Cui Weiyingqi W Chen Yi Y Guo Min M Wang Yongfang Y Xu Haiyan H Kurzay Annina A Alici Evren E Holmgren Lars L Haglund Felix F Wang Kai K Lundqvist Andreas A
The Journal of clinical investigation 20201001 10
To improve the clinical outcome of adoptive NK cell therapy in patients with solid tumors, NK cells need to persist within the tumor microenvironment (TME) in which the abundance of ROS could dampen antitumor immune responses. In the present study, we demonstrated that IL-15-primed NK cells acquired resistance against oxidative stress through the thioredoxin system activated by mTOR. Mechanistically, the activation of thioredoxin showed dependence on localization of thioredoxin-interacting prote ...[more]