Modelling the emergence of whisker barrels.
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ABSTRACT:
SUBMITTER: James SS
PROVIDER: S-EPMC7524548 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Modelling the emergence of whisker barrels.
James Sebastian S SS Krubitzer Leah A LA Wilson Stuart P SP
eLife 20200929
Brain development relies on an interplay between genetic specification and self-organization. Striking examples of this relationship can be found in the somatosensory brainstem, thalamus, and cortex of rats and mice, where the arrangement of the facial whiskers is preserved in the arrangement of cell aggregates to form precise somatotopic maps. We show in simulation how realistic whisker maps can self-organize, by assuming that information is exchanged between adjacent cells only, under the guid ...[more]
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