Ontology highlight
ABSTRACT:
SUBMITTER: Avraham O
PROVIDER: S-EPMC7524726 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Avraham Oshri O Deng Pan-Yue PY Jones Sara S Kuruvilla Rejji R Semenkovich Clay F CF Klyachko Vitaly A VA Cavalli Valeria V
Nature communications 20200929 1
Peripheral sensory neurons regenerate their axon after nerve injury to enable functional recovery. Intrinsic mechanisms operating in sensory neurons are known to regulate nerve repair, but whether satellite glial cells (SGC), which completely envelop the neuronal soma, contribute to nerve regeneration remains unexplored. Using a single cell RNAseq approach, we reveal that SGC are distinct from Schwann cells and share similarities with astrocytes. Nerve injury elicits changes in the expression of ...[more]