Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition.
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ABSTRACT:
SUBMITTER: Francisco J
PROVIDER: S-EPMC7524792 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition.
Francisco Jamie J Zhang Yu Y Jeong Jae Im JI Mizushima Wataru W Ikeda Shohei S Ivessa Andreas A Oka Shinichi S Zhai Peiyong P Tallquist Michelle D MD Del Re Dominic P DP
JACC. Basic to translational science 20200928 9
Fibrotic remodeling of the heart in response to injury contributes to heart failure, yet therapies to treat fibrosis remain elusive. Yes-associated protein (YAP) is activated in cardiac fibroblasts by myocardial infarction, and genetic inhibition of fibroblast YAP attenuates myocardial infarction-induced cardiac dysfunction and fibrosis. YAP promotes myofibroblast differentiation and associated extracellular matrix gene expression through engagement of TEA domain transcription factor 1 and subse ...[more]
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