Immune response and endocytosis pathways are associated with the resilience against Alzheimer's disease.

ABSTRACT: Developing Alzheimer's disease (AD) is influenced by multiple genetic variants that are involved in five major AD-pathways. Per individual, these pathways may differentially contribute to the modification of the AD-risk. The pathways involved in the resilience against AD have thus far been poorly addressed. Here, we investigated to what extent each molecular mechanism associates with (i) the increased risk of AD and (ii) the resilience against AD until extreme old age, by comparing pathway-specific polygenic risk scores (pathway-PRS). We used 29 genetic variants associated with AD to develop pathway-PRS for five major pathways involved in AD. We developed an integrative framework that allows multiple genes to associate with a variant, and multiple pathways to associate with a gene. We stud

SUBMITTER: Tesi N 

PROVIDER: S-EPMC7524800 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature