Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC7525432 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Wang Shaoxun S Lv Wenshan W Zhang Huawei H Liu Yedan Y Li Longyang L Jefferson Joshua R JR Guo Ya Y Li Man M Gao Wenjun W Fang Xing X Paul Ian A IA Rajkowska Grazyna G Shaffery James P JP Mosley Thomas H TH Hu Xinlin X Liu Ruen R Wang Yangang Y Yu Hongwei H Roman Richard J RJ Fan Fan F
GeroScience 20200721 5
Diabetes mellitus (DM) is a leading risk factor for aging-related dementia; however, the underlying mechanisms are not well understood. The present study, utilizing a non-obese T2DN diabetic model, demonstrates that the myogenic response of the middle cerebral artery (MCA) and parenchymal arteriole (PA) and autoregulation of cerebral blood flow (CBF) in the surface and deep cortex were impaired at both young and old ages. The impaired CBF autoregulation was more severe in old than young DM rats, ...[more]