Changes in Fibroblast Growth Factor 23 and Soluble Klotho Levels After Hemodialysis Initiation.

ABSTRACT:

Rationale & objective

Patients with chronic kidney failure have markedly elevated fibroblast growth factor 23 (FGF-23) levels and decreased soluble Klotho levels. However, no studies have examined the effects of hemodialysis initiation on the levels of these hormones and other parameters of mineral metabolism.

Study design

Prospective single-arm study.

Setting & participants

20 individuals with incident kidney failure initiating hemodialysis.

Exposure

Initiation of hemodialysis. Dose adjustments of phosphate binders and vitamin D receptor activators and use of calcimimetics, erythropoiesis-stimulating agents, and intravenous iron were prohibited.

Outcomes

Changes in serum levels of FGF-23, soluble Klotho, and other biochemical parameters of mineral metab

SUBMITTER: Kawabata C 

PROVIDER: S-EPMC7525799 | biostudies-literature | 2020 Jan-Feb

REPOSITORIES: biostudies-literature