Sleep disturbances and inflammatory gene expression among pregnant women: Differential responses by race.

ABSTRACT: Excessive inflammation in pregnancy predicts adverse birth outcomes, including shortened gestational length and lower birthweight, with African American women at greater risk. As substantial racial disparities in sleep quality, and evidence that African Americans have increased vulnerability for sleep-induced inflammatory dysregulation, sleep may be a critical, modifiable health behavior that contributes to racial disparities in birth outcomes. The present study examined sleep disturbance as a predictor of genome-wide transcriptome profiles of peripheral blood samples from 103 pregnant women (33 African American, 70 white) assessed at 18.7 ± 7.2 weeks gestation. We hypothesized that pregnant women with significant sleep disturbances would have gene expression profiles indicating over-expre

SUBMITTER: Carroll JE 

PROVIDER: S-EPMC7526416 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature