Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC7526480 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Li Zhiguo Z Li Minshu M Shi Samuel X SX Yao Nan N Cheng Xiaojing X Guo Ai A Zhu Zilong Z Zhang Xiaoan X Liu Qiang Q
The Journal of experimental medicine 20201201 12
Perihematomal edema (PHE) occurs within hours after intracerebral hemorrhage (ICH), leading to secondary injury manifested by impaired blood-brain barrier (BBB) integrity and destruction of adjacent tissue. To dissect the mechanisms underlying PHE formation, we profiled human and mouse perihematomal tissues and identified natural killer (NK) cells as the predominant immune cell subset that outnumbers other infiltrating immune cell types during early stages of ICH. Unbiased clustering of single-c ...[more]