Ontology highlight
ABSTRACT:
SUBMITTER: Owczarczyk K
PROVIDER: S-EPMC7526555 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Owczarczyk Kasia K Cascino Matthew D MD Holweg Cecile C Tew Gaik W GW Ortmann Ward W Behrens Timothy T Schindler Thomas T Langford Carol A CA St Clair E William EW Merkel Peter A PA Spiera Robert R Seo Philip P Kallenberg Cees Gm CG Specks Ulrich U Lim Noha N Stone John J Brunetta Paul P Prunotto Marco M
JCI insight 20200917 18
BACKGROUNDBaseline expression of FCRL5, a marker of naive and memory B cells, was shown to predict response to rituximab (RTX) in rheumatoid arthritis. This study investigated baseline expression of FCRL5 as a potential biomarker of clinical response to RTX in granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA).METHODSA previously validated quantitative PCR-based (qPCR-based) platform was used to assess FCRL5 expression in patients with GPA/MPA (RAVE trial, NCT00104299).RES ...[more]