Ontology highlight
ABSTRACT:
SUBMITTER: McNeil MB
PROVIDER: S-EPMC7526845 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
McNeil Matthew B MB Ryburn Heath W K HWK Harold Liam K LK Tirados Justin F JF Cook Gregory M GM
Antimicrobial agents and chemotherapy 20200722 8
Bedaquiline, an inhibitor of the mycobacterial ATP synthase, has revolutionized the treatment of <i>Mycobacterium tuberculosis</i> infection. Although a potent inhibitor, it is characterized by poorly understood delayed time-dependent bactericidal activity. Here, we demonstrate that in contrast to bedaquiline, the transcriptional inhibition of the ATP synthase in <i>M. tuberculosis</i> and <i>Mycobacterium smegmatis</i> has rapid bactericidal activity. These results validate the mycobacterial AT ...[more]