Ontology highlight
ABSTRACT:
SUBMITTER: Popgeorgiev N
PROVIDER: S-EPMC7527217 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Science advances 20200930 40
In metazoans, Bcl-2 family proteins are major regulators of mitochondrially mediated apoptosis; however, their evolution remains poorly understood. Here, we describe the molecular characterization of the four members of the Bcl-2 family in the most primitive metazoan, <i>Trichoplax adhaerens</i> All four trBcl-2 homologs are multimotif Bcl-2 group, with trBcl-2L1 and trBcl-2L2 being highly divergent antiapoptotic Bcl-2 members, whereas trBcl-2L3 and trBcl-2L4 are homologs of proapoptotic Bax and ...[more]