Wireless battery-free wearable sweat sensor powered by human motion
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ABSTRACT:
SUBMITTER: Song Y
PROVIDER: S-EPMC7527225 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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Project description:We fabricated wearable perspiration analyzing sites for actively monitoring physiological status during exercises without any batteries or other power supply. The device mainly consists of ZnO nanowire (NW) arrays and flexible polydimethylsiloxane substrate. Sweat on the skin can flow into the flow channels of the device through capillary action and flow along the channels to ZnO NWs. The sweat flowing on the NWs (with lactate oxidase modification) can output a DC electrical signal, and the outputting voltage is dependent on the lactate concentration in the sweat as the biosensing signal. ZnO NWs generate electric double layer (EDL) in sweat, which causes a potential difference between the upper and lower ends (hydrovoltaic effect). The product of the enzymatic reaction can adjust the EDL and influence the output. This device can be integrated with wireless transmitter and may have potential application in constructing sports big data. This work promotes the development of next generation of biosensors and expands the scope of self-powered physiological monitoring system.
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Project description:The confluence of wireless technology and biosensors offers the possibility to detect and manage medical conditions outside of clinical settings. Wound infections represent a major clinical challenge in which timely detection is critical for effective interventions, but this is currently hindered by the lack of a monitoring technology that can interface with wounds, detect pathogenic bacteria, and wirelessly transmit data. Here, we report a flexible, wireless, and battery-free sensor that provides smartphone-based detection of wound infection using a bacteria-responsive DNA hydrogel. The engineered DNA hydrogels respond selectively to deoxyribonucleases associated with pathogenic bacteria through tunable dielectric changes, which can be wirelessly detected using near-field communication. In a mouse acute wound model, we demonstrate that the wireless sensor can detect physiologically relevant amounts of Staphylococcus aureus even before visible manifestation of infection. These results demonstrate strategies for continuous infection monitoring, which may facilitate improved management of surgical or chronic wounds.
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Project description:BackgroundThe characterization of limb biomechanics has broad implications for analyzing and managing motion in aging, sports, and disease. Motion capture videography and on-body wearable sensors are powerful tools for characterizing linear and angular motions of the body, though are often cumbersome, limited in detection, and largely non-portable. Here we examine the feasibility of utilizing an advanced wearable sensor, fabricated with stretchable electronics, to characterize linear and angular movements of the human arm for clinical feedback. A wearable skin-adhesive patch with embedded accelerometer and gyroscope (BioStampRC, MC10 Inc.) was applied to the volar surface of the forearm of healthy volunteers. Arms were extended/flexed for the range of motion of three different regimes: 1) horizontal adduction/abduction 2) flexion/extension 3) vertical abduction. Data were streamed and recorded revealing the signal "pattern" of movement in three separate axes. Additional signal processing and filtering afforded the ability to visualize these motions in each plane of the body; and the 3-dimensional motion envelope of the arm.ResultsEach of the three motion regimes studied had a distinct pattern - with identifiable qualitative and quantitative differences. Integration of all three movement regimes allowed construction of a "motion envelope," defining and quantifying motion (range and shape - including the outer perimeter of the extreme of motion - i.e. the envelope) of the upper extremity. The linear and rotational motion results from multiple arm motions match measurements taken with videography and benchtop goniometer.ConclusionsA conformal, stretchable electronic motion sensor effectively captures limb motion in multiple degrees of freedom, allowing generation of characteristic signatures which may be readily recorded, stored, and analyzed. Wearable conformal skin adherent sensor patchs allow on-body, mobile, personalized determination of motion and flexibility parameters. These sensors allow motion assessment while mobile, free of a fixed laboratory environment, with utility in the field, home, or hospital. These sensors and mode of analysis hold promise for providing digital "motion biomarkers" of health and disease.
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Project description:BackgroundSweat, as an easily accessible bodily fluid, is enriched with a lot of physiological and health information. A portable and wearable sweat sensor is an important device for an on-body health monitoring. However, there are only few such devices to monitor sweat. Based on the fact that sweat is mainly composed of moisture and salt which is much more abundant than other trace ions in sweat, a new route is proposed to realize wearable sweat sensors using CdSSe nanowire-chips coated with a polyimide (PI) membrane.ResultsFirstly, the composition-graded CdS1-xSex (x = 0-1) nanowire-chip based sensor shows good photo-sensitivity and stress sensitivity which induces linear humidity dependent conductivity. This indicates good moisture response with a maximum responsivity (dI/I) 244% at 80% relative humidity (RH) even in the dark. Furthermore, the linear current decrease with salt increase illustrates the chip sensor has a good salt-sensing ability with the best salt dependent responsivity of 80%, which guarantees the high prediction accuracy in sweat sensing. The sensor current is further proven to nonlinearly correlate to the amount of sweat with excellent stability, reproducibility and recoverability. The wearable sweat sensor is finally applied on-body real-time sweat analysis, showing good consistence with the body status during indoor exercise.ConclusionsThese results suggest that this CdSSe nanowire-chip based PI-coated integrated sensor, combined with inorganic and organic functional layers, provides a simple and reliable method to build up diverse portable and wearable devices for the applications on healthcare and athletic status.
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Project description:Increased development of wearable sensors for physiological monitoring has spurred complementary interest in the detection of biochemical indicators of health and performance. We report a wearable sensor system for non-invasive detection of excreted human biomarkers in sweat. The system consists of a thin, flexible, kapton patch (2.5 × 7.5 cm) that can be coated with adhesive and affixed to the skin. The system can be controlled by a cell phone via a near-field communications protocol, charged wirelessly, and the data can be downloaded and displayed in a smart phone app. The system is designed such that the sensing element plugs into a low-profile socket, and can easily be removed and replaced as needed due to saturation or aging effects. As a demonstration case, we examined using an organic electrochemical transistor (OECT) within this system to monitor lactate concentration. Several different methods for optimizing the sensor performance were compared, including altering electrode materials, employing various immobilization techniques, and tailoring operating voltages. Resulting functional response of the lactate oxidase enzyme was compared as a function of the sensor variables. The OECT sensor was shown to have high sensitivity to lactate, however the sensing range is limited to lactate concentrations below approximately 1 mM.
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