An atlas on risk factors for type 2 diabetes: a wide-angled Mendelian randomisation study.

ABSTRACT:

Aims/hypothesis

The aim of this study was to use Mendelian randomisation (MR) to identify the causal risk factors for type 2 diabetes.

Methods

We first conducted a review of meta-analyses and review articles to pinpoint possible risk factors for type 2 diabetes. Around 170 possible risk factors were identified of which 97 risk factors with available genetic instrumental variables were included in MR analyses. To reveal more risk factors that were not included in our MR analyses, we conducted a review of published MR studies of type 2 diabetes. For our MR analyses, we used summary-level data from the DIAbetes Genetics Replication And Meta-analysis consortium (74,124 type 2 diabetes cases and 824,006 controls of European ancestry). Potential causal associations were replicated

SUBMITTER: Yuan S 

PROVIDER: S-EPMC7527357 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature