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C-Met expression in renal cell carcinoma with bone metastases.

ABSTRACT: Hepatocyte growth factor (HGF)/c-Met pathway is implicated in embryogenesis and organ development and differentiation. Germline or somatic mutations, chromosomal rearrangements, gene amplification, and transcriptional upregulation in MET or alterations in autocrine or paracrine c-Met signalling have been associated with cancer cell proliferation and survival, including in renal cell carcinoma (RCC), and associated with disease progression. HGF/c-Met pathway has been shown to be particularly relevant in tumors with bone metastases (BMs). However, the efficacy of targeting c-Met in bone metastatic disease, including in RCC, has not been proven. Therefore, further investigation is required focusing the particular role of HGF/c-Met pathway in bone microenvironment (BME) and how to effectively target this pathway in the context of bone metastatic disease.

SUBMITTER: Silva Paiva R

PROVIDER: S-EPMC7527574 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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c-Met expression in renal cell carcinoma with bone metastases.

Silva Paiva Rita R Gomes Inês I Casimiro Sandra S Fernandes Isabel I Costa Luís L

Journal of bone oncology 20200916

Hepatocyte growth factor (HGF)/c-Met pathway is implicated in embryogenesis and organ development and differentiation. Germline or somatic mutations, chromosomal rearrangements, gene amplification, and transcriptional upregulation in <i>MET</i> or alterations in autocrine or paracrine c-Met signalling have been associated with cancer cell proliferation and survival, including in renal cell carcinoma (RCC), and associated with disease progression. HGF/c-Met pathway has been shown to be particular ...[more]

PMID: 33024658

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