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Prediction of Recombination Spots Using Novel Hybrid Feature Extraction Method via Deep Learning Approach.

ABSTRACT: Meiotic recombination is the driving force of evolutionary development and an important source of genetic variation. The meiotic recombination does not take place randomly in a chromosome but occurs in some regions of the chromosome. A region in chromosomes with higher rate of meiotic recombination events are considered as hotspots and a region where frequencies of the recombination events are lower are called coldspots. Prediction of meiotic recombination spots provides useful information about the basic functionality of inheritance and genome diversity. This study proposes an intelligent computational predictor called iRSpots-DNN for the identification of recombination spots. The proposed predictor is based on a novel feature extraction method and an optimized deep neural network (DNN). The DNN was employed as a classification engine whereas, the novel features extraction method was developed to extract meaningful features for the identification of hotspots and coldspots across the yeast genome. Unlike previous algorithms, the proposed feature extraction avoids bias among different selected features and preserved the sequence discriminant properties along with the sequence-structure information simultaneously. This study also considered other effective classifiers named support vector machine (SVM), K-nearest neighbor (KNN), and random forest (RF) to predict recombination spots. Experimental results on a benchmark dataset with 10-fold cross-validation showed that iRSpots-DNN achieved the highest accuracy, i.e., 95.81%. Additionally, the performance of the proposed iRSpots-DNN is significantly better than the existing predictors on a benchmark dataset. The relevant benchmark dataset and source code are freely available at: https://github.com/Fatima-Khan12/iRspot_DNN/tree/master/iRspot_DNN.

SUBMITTER: Khan F

PROVIDER: S-EPMC7527634 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Prediction of Recombination Spots Using Novel Hybrid Feature Extraction Method via Deep Learning Approach.

Khan Fatima F Khan Mukhtaj M Iqbal Nadeem N Khan Salman S Muhammad Khan Dost D Khan Abbas A Wei Dong-Qing DQ

Frontiers in genetics 20200917

Meiotic recombination is the driving force of evolutionary development and an important source of genetic variation. The meiotic recombination does not take place randomly in a chromosome but occurs in some regions of the chromosome. A region in chromosomes with higher rate of meiotic recombination events are considered as hotspots and a region where frequencies of the recombination events are lower are called coldspots. Prediction of meiotic recombination spots provides useful information about ...[more]

PMID: 33093842

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Project description:BackgroundHot spots are interface residues that contribute most binding affinity to protein-protein interaction. A compact and relevant feature subset is important for building machine learning methods to predict hot spots on protein-protein interfaces. Although different methods have been used to detect the relevant feature subset from a variety of features related to interface residues, it is still a challenge to detect the optimal feature subset for building the final model.ResultsIn this study, three different feature selection methods were compared to propose a new hybrid feature selection strategy. This new strategy was proved to effectively reduce the feature space when we were building the prediction models for identifying hotspot residues. It was tested on eighty-two features, both conventional and newly proposed. According to the strategy, combining the feature subsets selected by decision tree and mRMR (maximum Relevance Minimum Redundancy) individually, we were able to build a model with 6 features by using a PSFS (Pseudo Sequential Forward Selection) process. Compared with other state-of-art methods for the independent test set, our model had shown better or comparable predictive performances (with F-measure 0.622 and recall 0.821). Analysis of the 6 features confirmed that our newly proposed feature CNSV_REL1 was important for our model. The analysis also showed that the complementarity between features should be considered as an important aspect when conducting the feature selection.ConclusionIn this study, most important of all, a new strategy for feature selection was proposed and proved to be effective in selecting the optimal feature subset for building prediction models, which can be used to predict hot spot residues on protein-protein interfaces. Moreover, two aspects, the generalization of the single feature and the complementarity between features, were proved to be of great importance and should be considered in feature selection methods. Finally, our newly proposed feature CNSV_REL1 had been proved an alternative and effective feature in predicting hot spots by our study. Our model is available for users through a webserver: http://zhulab.ahu.edu.cn/iPPHOT/ .

Dataset Information

Prediction of Recombination Spots Using Novel Hybrid Feature Extraction Method via Deep Learning Approach.

Publications

Prediction of Recombination Spots Using Novel Hybrid Feature Extraction Method via Deep Learning Approach.

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