Ontology highlight
ABSTRACT:
SUBMITTER: Trajanoska K
PROVIDER: S-EPMC7527955 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Communications biology 20200930 1
Both extrinsic and intrinsic factors predispose older people to fall. We performed a genome-wide association analysis to investigate how much of an individual's fall susceptibility can be attributed to genetics in 89,076 cases and 362,103 controls from the UK Biobank Study. The analysis revealed a small, but significant SNP-based heritability (2.7%) and identified three novel fall-associated loci (P<sub>combined</sub> ≤ 5 × 10<sup>-8</sup>). Polygenic risk scores in two independent settings show ...[more]