Genetic basis of falling risk susceptibility in the UK Biobank Study.

ABSTRACT: Both extrinsic and intrinsic factors predispose older people to fall. We performed a genome-wide association analysis to investigate how much of an individual's fall susceptibility can be attributed to genetics in 89,076 cases and 362,103 controls from the UK Biobank Study. The analysis revealed a small, but significant SNP-based heritability (2.7%) and identified three novel fall-associated loci (P_combined ≤ 5 × 10^-8). Polygenic risk scores in two independent settings showed patterns of polygenic inheritance. Risk of falling had positive genetic correlations with fractures, identifying for the first time a pathway independent of bone mineral density. There were also positive genetic correlations with insomnia, neuroticism, depressive symptoms, and different medicatio

SUBMITTER: Trajanoska K 

PROVIDER: S-EPMC7527955 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature