Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Author Correction: Genome-wide human brain eQTLs: In-depth analysis and insights using the UKBEC dataset.

ABSTRACT: An amendment to this paper has been published and can be accessed via a link at the top of the paper.

SUBMITTER: Sng LMF

PROVIDER: S-EPMC7527956 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Author Correction: Genome-wide human brain eQTLs: In-depth analysis and insights using the UKBEC dataset.

Sng Letitia M F LMF Thomson Peter C PC Trabzuni Daniah D

Scientific reports 20201001 1

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...[more]

PMID: 32999326

Similar Datasets

Genome-wide human brain eQTLs: In-depth analysis and insights using the UKBEC dataset.

Project description:Understanding the complexity of the human brain transcriptome architecture is one of the most important human genetics study areas. Previous studies have applied expression quantitative trait loci (eQTL) analysis at the genome-wide level of the brain to understand the underlying mechanisms relating to neurodegenerative diseases, primarily at the transcript level. To increase the resolution of our understanding, the current study investigates multi/single-region, transcript/exon-level and cis versus trans-acting eQTL, across 10 regions of the human brain. Some of the key findings of this study are: (i) only a relatively small proportion of eQTLs will be detected, where the sensitivity is under 5%; (ii) when an eQTL is acting in multiple regions (MR-eQTL), it tends to have very similar effects on gene expression in each of these regions, as well as being cis-acting; (iii) trans-acting eQTLs tend to have larger effects on expression compared to cis-acting eQTLs and tend to be specific to a single region (SR-eQTL) of the brain; (iv) the cerebellum has a very large number of eQTLs that function exclusively in this region, compared with other regions of the brain; (v) importantly, an interactive visualisation tool (Shiny app) was developed to visualise the MR/SR-eQTL at transcript and exon levels.

| S-EPMC6915738 | biostudies-literature

Author Correction: Optimized minimal genome-wide human sgRNA library.

Project description: Not available

| S-EPMC10432551 | biostudies-literature

Author Correction: Elephant shark genome provides unique insights into gnathostome evolution.

Project description:An amendment to this paper has been published and can be accessed via a link at the top of the paper.

| S-EPMC7962561 | biostudies-literature

Author Correction: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies.

Project description:An amendment to this paper has been published and can be accessed via a link at the top of the paper.

| S-EPMC7109051 | biostudies-literature

Author Correction: Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development.

Project description: Not available

| S-EPMC8924219 | biostudies-literature

Author Correction: Genome-wide simple sequence repeats (SSR) markers discovered from whole-genome sequence comparisons of multiple spinach accessions.

Project description: Not available

| S-EPMC9399093 | biostudies-literature

Author Correction: The Phytophthora cactorum genome provides insights into the adaptation to host defense compounds and fungicides.

Project description:An amendment to this paper has been published and can be accessed via a link at the top of the paper.

| S-EPMC7193557 | biostudies-literature

Author Correction: Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.

Project description: Not available

| S-EPMC9492759 | biostudies-literature

Author Correction: Genetically engineered cerebral organoids model brain tumor formation.

Project description:In the originally published paper, the "before" image for the afatinib condition in Fig. 6c was incorrect. Instead of an image displaying a GBM-3 neoplastic organoid before afatinib treatment, this panel showed an image from the GBM-2 control (DMSO) group before treatment. This error has now been corrected in the HTML and PDF versions of the article; the "before, afatinib" panel in Fig. 6c now shows a representative image from the indicated experiment. The color of all error bars in Fig. 6 has also been changed to black, for consistency. All statistical analysis and all conclusions presented in the article are unaffected by this error. Nevertheless, we apologize for the mistake.

| S-EPMC6345371 | biostudies-literature

Author Correction: A simulated Northern Hemisphere terrestrial climate dataset for the past 60,000 years.

Project description:An amendment to this paper has been published and can be accessed via a link at the top of the paper.

| S-EPMC7064586 | biostudies-literature