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Prospective study of live attenuated vaccines for patients receiving immunosuppressive agents.

ABSTRACT: Patients receiving immunosuppressive agents are at risk of life-threatening infections. However, live vaccines are generally contraindicated in them. We conducted a prospective study regarding live attenuated vaccines for them. Patients elder than one year of age with immunosuppressive agents who showed negative or borderline antibody titers (virus-specific IgG levels < 4.0) against one or more of measles, rubella, varicella, and mumps and fulfilled the criteria (CD4 cell counts ? 500/mm3, stimulation index of lymphocyte blast transformation by PHA ? 101.6, serum IgG level ? 300 mg/dl, no steroid use or prednisolone < 1 mg/kg/day or < 2 mg/kg/2 days, trough levels of tacrolimus or cyclosporine were < 10 ng/ml or < 100 ng/ml and under good control of primary disease) were enrolled. Sixty-four vaccinations were administered to 32 patients. The seroconversion rates for measles, rubella, varicella, and mumps were 80.0%, 100.0%, 59.1%, and 69.2%, respectively. No life-threatening adverse events were observed, although one patient suffered from vaccine-strain varicella who showed cellular and humoral immunodeficiency (CD4 cell counts = 511/mm3, stimulation index of lymphocyte blast transformation by PHA = 91.1, serum IgG level = 208 mg/dl). This girl was immunized before we established the criteria for vaccination. Immunization with live attenuated vaccines for patients receiving immunosuppressive agents might be effective and safe if their cellular and humoral immunological parameters are within normal levels. However, determining the criteria for vaccination by immunological parameters should be established to guarantee the safety of live vaccines in the future. Clinical Trial Registration: UMIN Clinical Trials Registry (UMIN-CTR) UMIN000007710. The date of registration: 2012/4/13.

SUBMITTER: Kamei K

PROVIDER: S-EPMC7529194 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Prospective study of live attenuated vaccines for patients receiving immunosuppressive agents.

Kamei Koichi K Miyairi Isao I Ishikura Kenji K Ogura Masao M Shoji Kensuke K Arai Katsuhiro K Ito Reiko R Kawai Toshinao T Ito Shuichi S

PloS one 20201001 10

Patients receiving immunosuppressive agents are at risk of life-threatening infections. However, live vaccines are generally contraindicated in them. We conducted a prospective study regarding live attenuated vaccines for them. Patients elder than one year of age with immunosuppressive agents who showed negative or borderline antibody titers (virus-specific IgG levels < 4.0) against one or more of measles, rubella, varicella, and mumps and fulfilled the criteria (CD4 cell counts ≥ 500/mm3, stimu ...[more]

PMID: 33002085

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Prospective study of live attenuated vaccines for patients receiving immunosuppressive agents.

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Prospective study of live attenuated vaccines for patients receiving immunosuppressive agents.

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