Ontology highlight
ABSTRACT:
SUBMITTER: Lorton BM
PROVIDER: S-EPMC7529705 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Lorton Benjamin M BM Harijan Rajesh K RK Burgos Emmanuel S ES Bonanno Jeffrey B JB Almo Steven C SC Shechter David D
Biochemistry 20200331 39
Histone H3 arginine 2 (H3R2) is post-translationally modified in three different states by "writers" of the protein arginine methyltransferase (PRMT) family. H3R2 methylarginine isoforms include PRMT5-catalyzed monomethylation (me1) and symmetric dimethylation (me2s) and PRMT6-catalyzed me1 and asymmetric dimethylation (me2a). WD-40 repeat-containing protein 5 (WDR5) is an epigenetic "reader" protein that interacts with H3R2. Previous studies suggested that H3R2me2s specified a high-affinity int ...[more]