Ontology highlight
ABSTRACT:
SUBMITTER: Xin J
PROVIDER: S-EPMC7529806 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Xin Jingxue J Zhang Hui H He Yaoxi Y Duren Zhana Z Bai Caijuan C Chen Lang L Luo Xin X Yan Dong-Sheng DS Zhang Chaoyu C Zhu Xiang X Yuan Qiuyue Q Feng Zhanying Z Cui Chaoying C Qi Xuebin X Ouzhuluobu Wong Wing Hung WH Wang Yong Y Su Bing B
Nature communications 20201001 1
High-altitude adaptation of Tibetans represents a remarkable case of natural selection during recent human evolution. Previous genome-wide scans found many non-coding variants under selection, suggesting a pressing need to understand the functional role of non-coding regulatory elements (REs). Here, we generate time courses of paired ATAC-seq and RNA-seq data on cultured HUVECs under hypoxic and normoxic conditions. We further develop a variant interpretation methodology (vPECA) to identify acti ...[more]