Ontology highlight
ABSTRACT:
SUBMITTER: Gibbs DC
PROVIDER: S-EPMC7529852 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Gibbs David Corley DC Bostick Roberd M RM McCullough Marjorie L ML Um Caroline Y CY Flanders W Dana WD Jenab Mazda M Weiderpass Elisabete E Gylling Björn B Gram Inger T IT Heath Alicia K AK Colorado-Yohar Sandra S Dahm Christina C CC Bueno-de-Mesquita Bas B Perez-Cornago Aurora A Trichopoulou Antonia A Tumino Rosario R Kühn Tilman T Fedirko Veronika V
International journal of cancer 20200525 10
Lower prediagnostic circulating 25-hydroxyvitamin D (25[OH]D)-considered the best marker of total vitamin D exposure-is associated with higher mortality risk among colorectal cancer (CRC) patients. However, it is unknown whether this association differs by the vitamin D-binding protein (GC) isoform Gc2 (encoded by GC rs4588*C>A, Thr436Lys), which may substantially affect vitamin D metabolism and modify associations of 25(OH)D with colorectal neoplasm risk. Prediagnostic 25(OH)D-mortality associa ...[more]