Neanderthal introgression reintroduced functional ancestral alleles lost in Eurasian populations.
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ABSTRACT:
SUBMITTER: Rinker DC
PROVIDER: S-EPMC7529911 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Neanderthal introgression reintroduced functional ancestral alleles lost in Eurasian populations.
Rinker David C DC Simonti Corinne N CN McArthur Evonne E Shaw Douglas D Hodges Emily E Capra John A JA
Nature ecology & evolution 20200727 10
Neanderthal ancestry remains across modern Eurasian genomes and introgressed sequences influence diverse phenotypes. Here, we demonstrate that introgressed sequences reintroduced thousands of ancestral alleles that were lost in Eurasian populations before introgression. Our simulations and variant effect predictions argue that these reintroduced alleles (RAs) are more likely to be tolerated by modern humans than are introgressed Neanderthal-derived alleles (NDAs) due to their distinct evolutiona ...[more]
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