Ontology highlight
ABSTRACT:
SUBMITTER: Kaur N
PROVIDER: S-EPMC7529949 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Kaur Navjot N Han Wenqi W Li Zhuo Z Madrigal M Pilar MP Shim Sungbo S Pochareddy Sirisha S Gulden Forrest O FO Li Mingfeng M Xu Xuming X Xing Xiaojun X Takeo Yutaka Y Li Zhen Z Lu Kangrong K Imamura Kawasawa Yuka Y Ballester-Lurbe Begoña B Moreno-Bravo Juan Antonio JA Chédotal Alain A Terrado José J Pérez-Roger Ignacio I Koleske Anthony J AJ Sestan Nenad N
Neuron 20200723 6
Neural stem cells directly or indirectly generate all neurons and macroglial cells and guide migrating neurons by using a palisade-like scaffold made of their radial fibers. Here, we describe an unexpected role for the radial fiber scaffold in directing corticospinal and other axons at the junction between the striatum and globus pallidus. The maintenance of this scaffold, and consequently axon pathfinding, is dependent on the expression of an atypical RHO-GTPase, RND3/RHOE, together with its bi ...[more]