Ontology highlight
ABSTRACT:
SUBMITTER: Detter MR
PROVIDER: S-EPMC7530029 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Detter Matthew R MR Shenkar Robert R Benavides Christian R CR Neilson Catherine A CA Moore Thomas T Lightle Rhonda R Hobson Nicholas N Shen Le L Cao Ying Y Girard Romuald R Zhang Dongdong D Griffin Erin E Gallione Carol J CJ Awad Issam A IA Marchuk Douglas A DA
Angiogenesis 20200724 4
Cerebral cavernous malformations (CCMs) are ectatic capillary-venous malformations that develop in approximately 0.5% of the population. Patients with CCMs may develop headaches, focal neurologic deficits, seizures, and hemorrhages. While symptomatic CCMs, depending upon the anatomic location, can be surgically removed, there is currently no pharmaceutical therapy to treat CCMs. Several mouse models have been developed to better understand CCM pathogenesis and test therapeutics. The most common ...[more]