Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the Staphylococcus aureus receptor histidine kinase, AgrC.
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ABSTRACT:
SUBMITTER: Xie Q
PROVIDER: S-EPMC7530097 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the <i>Staphylococcus aureus</i> receptor histidine kinase, AgrC.
Xie Qian Q Wiedmann Mareike M MM Zhao Aishan A Pagan Ivelisse R IR Novick Richard P RP Suga Hiroaki H Muir Tom W TW
Chemical communications (Cambridge, England) 20200901 76
We combined mRNA display technology with lipid-nanodisc based selections and identified high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase AgrC as potent inhibitors of Staphylococcus aureus quorum sensing-modulated virulence. Our study highlights the potential of this integrated approach for identifying functional modulators of integral membrane proteins. ...[more]
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