Ontology highlight
ABSTRACT:
SUBMITTER: Chen NH
PROVIDER: S-EPMC7530546 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
The Journal of infectious diseases 20200101 3
L-lactate is an abundant metabolite in a number of niches in host organisms and represents an important carbon source for bacterial pathogens such as Neisseria gonorrhoeae. In this study, we describe an alternative, iron-sulfur cluster-containing L-lactate dehydrogenase (LutACB), that is distinct from the flavoprotein L-lactate dehydrogenase (LldD). Expression of lutACB was found to be positively regulated by iron, whereas lldD was more highly expressed under conditions of iron-limitation. The f ...[more]