Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids.
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ABSTRACT:
SUBMITTER: van der Graaf A
PROVIDER: S-EPMC7530717 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids.
van der Graaf Adriaan A Claringbould Annique A Rimbert Antoine A Westra Harm-Jan HJ Li Yang Y Wijmenga Cisca C Sanna Serena S
Nature communications 20201001 1
Inference of causality between gene expression and complex traits using Mendelian randomization (MR) is confounded by pleiotropy and linkage disequilibrium (LD) of gene-expression quantitative trait loci (eQTL). Here, we propose an MR method, MR-link, that accounts for unobserved pleiotropy and LD by leveraging information from individual-level data, even when only one eQTL variant is present. In simulations, MR-link shows false-positive rates close to expectation (median 0.05) and high power (u ...[more]
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