Ontology highlight
ABSTRACT:
SUBMITTER: Lin CH
PROVIDER: S-EPMC7530774 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Lin Cheng-Han CH Hsu Tai-I TI Chiou Pei-Yu PY Hsiao Michael M Wang Wen-Ching WC Chen Yu-Chia YC Lin Jen-Tai JT Wang Jaw-Yuan JY Lin Peng-Chan PC Lin Forn-Chia FC Tseng Yu-Kai YK Cheng Hui-Chuan HC Chen Chi-Long CL Lu Pei-Jung PJ
Molecular oncology 20200825 10
Mammalian STE20-like kinase 1 (MST1/STK4/KRS2) encodes a serine/threonine kinase that is the mammalian homolog of Drosophila Hippo. STK4 plays an important role in controlling cell growth, apoptosis, and organ size. STK4 has been studied in many cancers with previous studies indicating an involvement in colon cancer lymph node metastasis and highlighting its potential as a diagnostic marker for colon cancer. However, the role of STK4 defect in promoting colon cancer progression is still understu ...[more]