Eosinophil and mast cell Siglecs: From biology to drug target.
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ABSTRACT:
SUBMITTER: O'Sullivan JA
PROVIDER: S-EPMC7531194 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Eosinophil and mast cell Siglecs: From biology to drug target.
O'Sullivan Jeremy A JA Chang Alan T AT Youngblood Bradford A BA Bochner Bruce S BS
Journal of leukocyte biology 20200122 1
Mast cells and eosinophils are innate immune cells involved in both acute and chronic inflammatory responses. Siglecs are a family of cell surface receptors that share sialic acid binding activity. Over the past 20 years, our knowledge of the expression and function of Siglecs on cells of the immune system and others has greatly expanded, as has our understanding of their signaling, ligands, and possible roles in disease pathophysiology. Because of this, Siglecs have garnered interest as potenti ...[more]
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