Ontology highlight
ABSTRACT:
SUBMITTER: Nelson CW
PROVIDER: S-EPMC7531306 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Molecular biology and evolution 20200801 8
Purifying (negative) natural selection is a hallmark of functional biological sequences, and can be detected in protein-coding genes using the ratio of nonsynonymous to synonymous substitutions per site (dN/dS). However, when two genes overlap the same nucleotide sites in different frames, synonymous changes in one gene may be nonsynonymous in the other, perturbing dN/dS. Thus, scalable methods are needed to estimate functional constraint specifically for overlapping genes (OLGs). We propose OLG ...[more]