AlbuCORE: an albumin-based molecular scaffold for multivalent biologics design.

ABSTRACT: As biologics have become a mainstay in the development of novel therapies, protein engineering tools to expand on their structural advantages, namely specificity, affinity, and valency are of interest. Antibodies have dominated this field as the preferred scaffold for biologics development while there has been limited exploration into the use of albumin with its unique physiological characteristics as a platform for biologics design. There has been a great deal of interest to create bispecific and more complex multivalent molecules to build on the advantages offered by protein-based therapeutics relative to small molecules. Here, we explore the use of human serum albumin (HSA) as a scaffold for the design of multispecific biologics. In particular, we describe a structure-guided approach to

SUBMITTER: Sanches M 

PROVIDER: S-EPMC7531512 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature