Ontology highlight
ABSTRACT:
SUBMITTER: Zuchelkowski BE
PROVIDER: S-EPMC7531777 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Zuchelkowski Benjamin E BE Wang Ling L Gingras Sebastien S Xu Qinzi Q Yang Minying M Triulzi Darrell D Page Grier P GP Gordeuk Victor R VR Kim-Shapiro Daniel B DB Lee Janet S JS Gladwin Mark T MT
PloS one 20201002 10
<h4>Background</h4>Hydroxychloroquine (HCQ) is widely used in the treatment of malaria, rheumatologic disease such as lupus, and most recently, COVID-19. These uses raise concerns about its safe use in the setting of glucose-6-phosphate dehydrogenase (G6PD) deficiency, especially as 11% of African American men carry the G6PD A- variant. However, limited data exist regarding the safety of HCQ in this population.<h4>Study design and methods</h4>Recently, we created a novel "humanized" mouse model ...[more]