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Disease trajectory browser for exploring temporal, population-wide disease progression patterns in 7.2 million Danish patients.

ABSTRACT: We present the Danish Disease Trajectory Browser (DTB), a tool for exploring almost 25 years of data from the Danish National Patient Register. In the dataset comprising 7.2 million patients and 122 million admissions, users can identify diagnosis pairs with statistically significant directionality and combine them to linear disease trajectories. Users can search for one or more disease codes (ICD-10 classification) and explore disease progression patterns via an array of functionalities. For example, a set of linear trajectories can be merged into a disease trajectory network displaying the entire multimorbidity spectrum of a disease in a single connected graph. Using data from the Danish Register for Causes of Death mortality is also included. The tool is disease-agnostic across both rare and common diseases and is showcased by exploring multimorbidity in Down syndrome (ICD-10 code Q90) and hypertension (ICD-10 code I10). Finally, we show how search results can be customized and exported from the browser in a format of choice (i.e. JSON, PNG, JPEG and CSV).

SUBMITTER: Siggaard T

PROVIDER: S-EPMC7532164 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Disease trajectory browser for exploring temporal, population-wide disease progression patterns in 7.2 million Danish patients.

Siggaard Troels T Reguant Roc R Jørgensen Isabella F IF Haue Amalie D AD Lademann Mette M Aguayo-Orozco Alejandro A Hjaltelin Jessica X JX Jensen Anders Boeck AB Banasik Karina K Brunak Søren S

Nature communications 20201002 1

We present the Danish Disease Trajectory Browser (DTB), a tool for exploring almost 25 years of data from the Danish National Patient Register. In the dataset comprising 7.2 million patients and 122 million admissions, users can identify diagnosis pairs with statistically significant directionality and combine them to linear disease trajectories. Users can search for one or more disease codes (ICD-10 classification) and explore disease progression patterns via an array of functionalities. For ex ...[more]

PMID: 33009368

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Dataset Information

Disease trajectory browser for exploring temporal, population-wide disease progression patterns in 7.2 million Danish patients.

Publications

Disease trajectory browser for exploring temporal, population-wide disease progression patterns in 7.2 million Danish patients.

Similar Datasets

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