Ontology highlight
ABSTRACT:
SUBMITTER: Yin W
PROVIDER: S-EPMC7532165 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Yin Wenjing W Brittain Derrick D Borseth Jay J Scott Marie E ME Williams Derric D Perkins Jedediah J Own Christopher S CS Murfitt Matthew M Torres Russel M RM Kapner Daniel D Mahalingam Gayathri G Bleckert Adam A Castelli Daniel D Reid David D Lee Wei-Chung Allen WA Graham Brett J BJ Takeno Marc M Bumbarger Daniel J DJ Farrell Colin C Reid R Clay RC da Costa Nuno Macarico NM
Nature communications 20201002 1
Electron microscopy (EM) is widely used for studying cellular structure and network connectivity in the brain. We have built a parallel imaging pipeline using transmission electron microscopes that scales this technology, implements 24/7 continuous autonomous imaging, and enables the acquisition of petascale datasets. The suitability of this architecture for large-scale imaging was demonstrated by acquiring a volume of more than 1 mm<sup>3</sup> of mouse neocortex, spanning four different visual ...[more]