Correlation of Serum Cardiac Markers with Acute Decompensating Events in Liver Cirrhosis.

ABSTRACT: Methods:Cirrhotic patients who were consecutively hospitalized between January 2016 and March 2019 were screened. Serum cardiac biomarkers at admission, including N-Terminal pro-B-type natriuretic peptide (NT-pro BNP), high-sensitivity cardiac troponin T (hs-cTnT), creatine kinase (CK), creatine kinase MB (CK-MB), and lactate dehydrogenase (LDH), were collected. Acute decompensating events at admission, primarily including ascites, acute gastrointestinal hemorrhage, and acute-on-chronic liver failure (ACLF), were recorded. Results:The NT-pro BNP level was significantly higher in cirrhotic patients with acute decompensating events than in those without any decompensating events (median: 140.75?pg/mL versus 41.86?pg/mL, P < 0.001). The NT-pro BNP level significantly correlated with ascites, acute gastrointestinal hemorrhage, and ACLF. The hs-cTnT level was significantly higher in cirrhotic patients with acute decompensating events than in those without decompensating events (median: 0.008?ng/mL versus 0.006?ng/mL, P = 0.007). The hs-cTnT level significantly correlated with acute gastrointestinal hemorrhage, but not ascites or ACLF. LDH (185.0?U/L versus 173.5?U/L, P = 0.281), CK (71?U/L versus 84?U/L, P = 0.157), and CK-MB (29.5?U/L versus 33.0?U/L, P = 0.604) levels were not significantly different between cirrhotic patients with and without acute decompensating events. Conclusion:The elevated NT-pro BNP level seems to be closely related to the development of acute decompensating events in liver cirrhosis.

SUBMITTER: Li M 

PROVIDER: S-EPMC7532360 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature