Ontology highlight
ABSTRACT:
SUBMITTER: Morante S
PROVIDER: S-EPMC7533540 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Morante Silvia S La Penna Giovanni G Rossi Giancarlo G Stellato Francesco F
Frontiers in molecular biosciences 20200917
Zinc plays a crucial role in the process of virion maturation inside the host cell. The accessory Cys-rich proteins expressed in SARS-CoV-2 by genes ORF7a and ORF8 are likely involved in zinc binding and in interactions with cellular antigens activated by extensive disulfide bonds. In this report we provide a proof of concept for the feasibility of a structural study of orf7a and orf8 proteins. A conceivable hypothesis is that lack of cellular zinc, or substitution thereof, might lead to a signi ...[more]