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SARS-CoV-2 Virion Stabilization by Zn Binding.


ABSTRACT: Zinc plays a crucial role in the process of virion maturation inside the host cell. The accessory Cys-rich proteins expressed in SARS-CoV-2 by genes ORF7a and ORF8 are likely involved in zinc binding and in interactions with cellular antigens activated by extensive disulfide bonds. In this report we provide a proof of concept for the feasibility of a structural study of orf7a and orf8 proteins. A conceivable hypothesis is that lack of cellular zinc, or substitution thereof, might lead to a significant slowing down of viral maturation.

SUBMITTER: Morante S 

PROVIDER: S-EPMC7533540 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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SARS-CoV-2 Virion Stabilization by Zn Binding.

Morante Silvia S   La Penna Giovanni G   Rossi Giancarlo G   Stellato Francesco F  

Frontiers in molecular biosciences 20200917


Zinc plays a crucial role in the process of virion maturation inside the host cell. The accessory Cys-rich proteins expressed in SARS-CoV-2 by genes ORF7a and ORF8 are likely involved in zinc binding and in interactions with cellular antigens activated by extensive disulfide bonds. In this report we provide a proof of concept for the feasibility of a structural study of orf7a and orf8 proteins. A conceivable hypothesis is that lack of cellular zinc, or substitution thereof, might lead to a signi  ...[more]

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