Ontology highlight
ABSTRACT:
SUBMITTER: Krenn PW
PROVIDER: S-EPMC7533676 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Krenn Peter William PW Koschmieder Steffen S Fässler Reinhard R
Proceedings of the National Academy of Sciences of the United States of America 20200914 39
Kindlin-3 (K3)-mediated integrin adhesion controls homing and bone marrow (BM) retention of normal hematopoietic cells. However, the role of K3 in leukemic stem cell (LSC) retention and growth in the remodeled tumor-promoting BM is unclear. We report that loss of K3 in a mouse model of chronic myeloid leukemia (CML) triggers the release of LSCs from the BM into the circulation and impairs their retention, proliferation, and survival in secondary organs, which curbs CML development, progression, ...[more]