Ontology highlight
ABSTRACT:
SUBMITTER: Habel JR
PROVIDER: S-EPMC7533701 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Habel Jennifer R JR Nguyen Thi H O THO van de Sandt Carolien E CE Juno Jennifer A JA Chaurasia Priyanka P Wragg Kathleen K Koutsakos Marios M Hensen Luca L Jia Xiaoxiao X Chua Brendon B Zhang Wuji W Tan Hyon-Xhi HX Flanagan Katie L KL Doolan Denise L DL Torresi Joseph J Chen Weisan W Wakim Linda M LM Cheng Allen C AC Doherty Peter C PC Petersen Jan J Rossjohn Jamie J Wheatley Adam K AK Kent Stephen J SJ Rowntree Louise C LC Kedzierska Katherine K
Proceedings of the National Academy of Sciences of the United States of America 20200910 39
An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strategies. Experience with influenza shows that infection primes CD8<sup>+</sup> T cell memory to peptides presented by common HLA types like HLA-A2, which enhances recovery and diminishes clinical severity upon reinfection. Stimulating peripheral blood mononuclear cells from COVID-19 convalescent patients with overlapping peptides from severe acute respiratory syndrome co ...[more]