Fertility Impact of Initial Operation Type for Female Ulcerative Colitis Patients.

ABSTRACT:

Background

Ileal pouch-anal anastomosis (IPAA) is the mainstay of surgical treatment for patients with ulcerative colitis (UC) but is associated with an increased risk of infertility. We developed a simulation model examining the impact of initial surgical procedure on quality-adjusted life-years (QALYs) and fertility end points.

Methods

A patient-level state transition model was used to analyze outcomes by surgical approach strategy for females of childbearing age. Initial surgical options included IPAA, rectal-sparing colectomy with end ileostomy (RCEI), and ileorectal anastomosis (IRA). The primary outcome examined was QALYs, whereas secondary outcomes included UC and fertility-associated end points.

Results

IPAA resulted in higher QALYs for patients aged 20-30 yea

SUBMITTER: Faye AS 

PROVIDER: S-EPMC7534416 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature