Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC7534582 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Li Meng M Chiang Ying-Ling YL Lyssiotis Costas A CA Teater Matthew R MR Hong Jun Young JY Shen Hao H Wang Ling L Hu Jing J Jing Hui H Chen Zhengming Z Jain Neeraj N Duy Cihangir C Mistry Sucharita J SJ Cerchietti Leandro L Cross Justin R JR Cantley Lewis C LC Green Michael R MR Lin Hening H Melnick Ari M AM
Cancer cell 20190601 6
Diffuse large B cell lymphomas (DLBCLs) are genetically heterogeneous and highly proliferative neoplasms derived from germinal center (GC) B cells. Here, we show that DLBCLs are dependent on mitochondrial lysine deacetylase SIRT3 for proliferation, survival, self-renewal, and tumor growth in vivo regardless of disease subtype and genetics. SIRT3 knockout attenuated B cell lymphomagenesis in VavP-Bcl2 mice without affecting normal GC formation. Mechanistically, SIRT3 depletion impaired glutamine ...[more]