Ontology highlight
ABSTRACT:
SUBMITTER: Tosh DK
PROVIDER: S-EPMC7534897 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Tosh Dilip K DK Toti Kiran S KS Hurst Brett L BL Julander Justin G JG Jacobson Kenneth A KA
Bioorganic & medicinal chemistry letters 20201005 23
Various (North)-methanocarba adenosine derivatives, containing rigid bicyclo[3.1.0]hexane ribose substitution, were screened for activity against representative viruses, and inhibition was observed after treatment of Enterovirus A71 with a 2-chloro-N<sup>6</sup>-1-cyclopropyl-2-methylpropan-1-yl derivative (17). µM activity was also seen when testing 17 against other enteroviruses in the Picornaviridae family. Based on this hit, structural congeners of 17, containing other N<sup>6</sup>-alkyl gr ...[more]